Bristol Myers Squibb — Zenbexus (iberdomide) $BMY
for relapsed or refractory multiple myeloma (combination therapy)
for relapsed or refractory multiple myeloma (combination therapy)
Multiple myeloma is a cancer of plasma cells, the white blood cells that normally make antibodies; it often causes no symptoms at first, then brings bone pain, anemia, kidney problems, and infections as it progresses. Zenbexus (iberdomide) is a pill that binds a protein called cereblon, redirecting the cell's recycling machinery to break down specific proteins that myeloma cells rely on. Because it attacks those proteins through a different route than existing myeloma drugs, combining it with other treatments may help control the cancer in people whose disease has come back or stopped responding.
This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapsed or refractory multiple myeloma (RRMM).
Source: ClinicalTrials.gov