About

Hereditary angioedema is an inherited disorder that causes unpredictable, recurrent swelling attacks in the hands, feet, face, gut, and throat, and swelling in the airway can be life-threatening. Deucrictibant is an oral small molecule that blocks the bradykinin B2 receptor, the docking site where a signaling protein called bradykinin triggers the fluid leakage behind these attacks. By blocking that receptor, the drug may calm an attack already underway, potentially offering people with HAE a pill they can take when swelling starts.