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AUG 10 2026
UPCOMING · 68 DAYS TO PDUFA

Takeda Pharmaceuticals oveporexton $TAK

for narcolepsy type 1

NDA · Priority Review

Accepted FEB 10 2026.

About

Narcolepsy type 1 is a chronic neurological disorder that disrupts sleep-wake cycles, causing severe daytime sleepiness, sudden muscle weakness (cataplexy), and fragmented nighttime sleep. Oveporexton is an oral small molecule that activates the orexin receptor 2, a key brain pathway for maintaining wakefulness. By mimicking natural wake-promoting signals, the drug could help stabilize sleep patterns and reduce daytime sleep attacks in people with this condition.