← Back to The Docket APR 1 2026
APPROVED · 121 DAYS AGO
— Alyftrek, Trikafta (vanzacaftor/tezacaftor/deutivacaftor, elexacaftor/tezacaftor/ivacaftor)
$VRTX
for cystic fibrosis
NDA
FDA approved expanded use of Alyftrek and Trikafta for cystic fibrosis treatment, increasing availability to ~95% of patients.
About
Cystic fibrosis is a genetic disorder that causes thick mucus to build up in the lungs and other organs, leading to frequent infections, breathing difficulties, and long-term organ damage. Alyftrek and Trikafta are combination drugs that work to improve the function of the defective protein underlying the disease. By helping this protein work better, these treatments may reduce mucus buildup and the resulting complications for a broad range of patients.