About

IgA nephropathy is a kidney disease in which the immune system inflames the glomeruli, the tiny filtering units that clean the blood, and aggressive cases can also attack the liver, skin, and heart. Povetacicept is a lab-made protein that binds and blocks two immune signals, BLyS and APRIL, that drive B cells to produce antibodies. Because those signals help generate the faulty IgA antibodies that clog the kidney, blocking them may reduce protein in the urine and help preserve kidney function.